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Production of IgG Antibodies and Enhanced Response of Nude Mice to DNP-AE-Dextran

From the Max-Planck-Institut für Immunbiologie, D-78 Freiburg, Stübeweg 51, West Germany

Abstract

DNP-AE-dextran, prepared by the binding of DNP--aminocaproyl residues to aminoethylated dextran (predominantly -1,6-linked), induced a T-independent anti-DNP antibody response in mice. However, certain differences were observed between the response to this antigen in normal and nude mice. Thus, the antibody titers of nu/nu mice from day 10 to 38 after immunization were significantly higher than those of nu/+ controls. Furthermore, DNP-AE-dextran induced a weak secondary response in nu/+ but not in nu/nu mice.

For both thymusless and normal mice the production of IgG in addition to IgM antibodies to DNP-AE-dextran could be established. The former included antibodies of the IgG₁ subclass which were considered to be particularly thymus dependent (1). The higher response of nu/nu mice was reflected mainly in the increased production of IgG antibodies. Under the influence of a graft-vs-host reaction, a 10-fold increase in antibody titers to DNP-AE-dextran was observed, due entirely to an enhanced IgG response.