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K Cell Cytotoxicity against Antibody-Coated Chicken Erythrocytes in Tumor-Bearing Mice: Its Development with Progressively Growing Tumor and the Effect of Immunization against the Tumor¹

From the Department of Surgery, University of Edinburgh, Medical School, Teviot Place, Edinburgh and the Department of Therapeutics, Immunlogy Laboratories, 2 Forrest Road, University of Edinburgh, Edinburgh

Abstract

Antibody-dependent (K cell) cytotoxic activity of spleen cells from mice bearing a chemically induced fibrosarcoma has been studied by using antibody-coated chicken erythrocytes as target cells. Spleen cells from tumor-bearing animals caused a significantly greater degree of target cells destruction than did those from control animals. The elevated cytotoxic activity in tumor-bearing animals increased with time after the tumor inoculation and correlated directly with the size of the tumor. The development of increased cytotoxic activity could be circumvented by surgical removal of the tumor. Mice that received x-irradiated tumor cells or x-irradiated tumor cells followed by a live challenge did not show a tumor growth and also failed to show increased K cell cytotoxic activity. It has been concluded that the increased K cell activity results directly from the active growth of the tumor. The role of K cells in immunosurveillance has been discussed.

Footnotes

¹ This work was supported by Cancer Research Campaign and Medical Research Council.

² Correspondence to: Dr. A. Ghaffar, Laboratory of Virology, Department of Microbiology, School of Medicine, P. O. Box 875, Biscayne Annexe, Miami, Florida, 33152.