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Effect of V_Ha Locus Allotype-Suppression on the Expression of Closely Linked V_Hx, V_Hy, and Cµn Genes in Heterozygous Rabbits¹

From the Department of Microbiology, University of Illinois at the Medical Center, Chicago, Illinois 60680

Abstract

Injection of a¹x^-y^-n⁸¹/a²x³²y³³n⁸² heterozygous rabbits at birth with anti-a2 allotype antiserum suppresses the production of the V_Ha² gene product a2 Ig as well as the expression of the closely linked C_µn gene product n82 but not of the closely linked V_Hx and V_Hy gene products x32 and y33. This effect is related to the appearance of a2 and n82 on the same IgM molecules whereas a2, x32, and y33 appear on different Ig molecules.

Footnotes

¹ This investigation was supported in part by United States Public Health Service Grant AI 07043.

² Supported by United States Public Health Service Training Grant AI 00335-06.

³ La Rabida Institute, University of Chicago, E. 65th Street at Lake Michigan, Chicago, Illinois 60649.