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Temporal Dependence of the Inhibition by Cytochalasin B of Antigen-Initiated Migration Inhibition Factor Production

From the Laboratory of Immunology and Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014

Abstract

The effects of cytochalasin B on the antigen recognition process have been examined using an in vitro assay of macrophage-inhibition factor (MIF) production by activated guinea pig T lymphocyte-enriched populations. The data indicate that cytochalasin B inhibits MIF production if added at the initiation of culture but not if added 2 hr after antigen. These data are interpreted as consistent with either an inhibition by cytochalasin B of the physical association of antigen-bearing macrophage and lymphocytes or with an inhibition of the access of antigen to the T lymphocyte receptor.