HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Bernard, A. Articles by Day, N. K. Search for Related Content PubMed Articles by Bernard, A. Articles by Day, N. K.

Complement Inhibitor(s) Released by Leukocytes

I. Pretreatment of Sheep Erythrocytes with Supernatants of Mouse Spleen and Thymus Cells Inhibit Whole Complement Activity and C2 Utilization¹

From the Sloan-Kettering Institute, New York, New York 10021, and the Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014

Abstract

Sheep erythrocytes pretreated with supernatants of mouse spleen or thymus cells become resistant to lysis by guinea pig complement. The inhibitory activity (IA) reduces the utilization of C2 by EAC
. Because IA binds to the surface of sheep erythrocytes and does not inhibit C irreversibly, it is probably a hitherto undescribed inhibitor of complement.

Footnotes

¹ This work was presented in part at the FASEB Meetings, Atlantic City, New Jersey, 1975 (1). Supported by Public Health Service Grants CA-08748-09 from the National Cancer Institute, and AI-11843 from the National Institute of Allergy and Infectious Diseases, The American Cancer Society, and the National Foundation—March of Dimes.

² Visiting Research Fellow, Sloan-Kettering Institute; Guest Worker, Biology Branch, National Cancer Institute. Supported by a fellowship from Delegation Generale a la recherche Scientifique et Technique, France. To whom reprints should be requested.