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Mouse Effector Functions Involved in the Antibody-Dependent Cellular Cytotoxicity to Xenogeneic Erythrocytes¹

From the Department of Experimental Therapeutics and Grace Cancer Drug Center, Roswell Park Memorial Institute, New York State Department of Health, Buffalo, New York 14263

Abstract

Mouse spleen cell populations were fractionated by carbonyl iron depletion and nylon wool column separation. The fractions were tested for phagocytic and lytic activity against antibody-coated ⁵¹Cr-labeled sheep red blood cells. Carbonyl iron resistant cells had no phagocytic activity but caused lysis at a relatively slow rate. Nylon wool column nonadherent cells had a similar effect. In contrast with the slow lytic action of these cells, nylon wool adherent cells or non-carbonyl iron-treated cells had phagocytic as well as rapid lytic action. Under the conditions studied, both rapid and slow lytic functions were saturable whereas the phagocytic function was not.

Footnotes

¹ This investigation was supported in part by United States Public Health Service Grants CA-15142 and CA-13038.

² Present address: Sidney Farber Cancer Center of Harvard University Medical School. Part of this work was done in fulfillment of the requirements for a Ph.D. degree in the Department of Biochemical Pharmacology, School of Pharmacy, New York State University at Buffalo.

³ To whom reprint requests should be sent.