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RNA and Protein Synthesis in Spontaneous Rosette Formation by T Lymphocytes¹

From the Memorial-Sloan Kettering Cancer Center, New York, New York 10021 and Fizioloski Institut, Medicinski Facultet, Beograde, Yugoslavia

Abstract

Formation of rosettes with sheep red blood cells (SRBC) by peripheral blood lymphocytes and thymocytes has been studied. Trypsinization of these cells abolishes the capacity to form SRBC-rosettes. The process of re-establishment of this capacity to form SRBC-rosettes, in vitro, has been shown by use of metabolic inhibitors to require transcription, translation, and protein synthesis. These observations are interpreted in terms of the T cell markers as the expression of a definitive process or step in lymphoid cell differentiation.

Footnotes

¹ This investigation was aided by the U.S. Public Health Service Research Grants, no. CA-08748-09 and no. CA-05826, National Cancer Institute no. AI-12251 from the National Institute for Allergy and Infectious Diseases; American Cancer Society; and the National Foundation March of Dimes.

² Memorial-Sloan Kettering Cancer Center, New York, New York 10021.

³ Present address: Fizioloski Institut, Medicinski Facultet, Beograd, Yugoslavia.