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Transplantation Immunology of the Anterior Chamber of the Eye

I. An Intra-Ocular Graft-Vs-Host Reaction (immunogenic Anterior Uveitis)¹

From the Departments of Cell Biology and Ophthalmology, University of Texas Health Science Center at Dallas, Texas 75235

Abstract

A graft-vs-host reaction (GVHR) expressed as an anterior uveitis was elicited within the anterior chambers of the eyes of F₁ hybrid rats by the inoculation of suspensions of allogeneic, parental lymph node cells. This response resembled local GVHRs induced in other sites, except for the failure of refractoriness to appear following resolution of the acute phase. Because lymphoid cells within the anterior chamber have been shown to leave and make an impact on the systemic immunologic apparatus of the recipient, rather than remain isolated within the eye, it was suggested that the vascular route by which these cells disseminate is an important determinant of whether refractoriness will ensue from a local GVHR.

Footnotes

¹ This work was supported by Research Grant AI-10678 from the Institute of Allergy and Infectious Diseases, and research contract GM-01683 from the National Institutes of Health, Bethesda, Maryland.

² Present address: Department of Ophthalmology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, 52242. Research conducted while a fellow in the Department of Surgery, University of Miami, Jackson Memorial Hospital, Miami, Florida, 33136.