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Alloantibody-Induced Cytotoxicity of Macrophages¹

From the Department of Experimental and Clinical Immunology, Institute of Microbiology, School of Medicine, Cracow, Poland

Abstract

Alloantibodies substantially alter the in vitro nonspecific cytotoxic effect of macrophages on bystanding allogeneic and xenogeneic target cells. Although the specific IgM alloantibody increased significantly the ability of parental macrophages to damage target cells, IgG alloantibody had an opposite effect and suppressed the macrophage cytotoxicity. Macrophages of F₁ hybrid mice were less affected by this treatment unless alloantibodies against both parental strains were added together. Parental macrophages exposed in vitro to the concomitant action of both IgM and IgG alloantibodies exhibited a diminished cytotoxicity toward target cells. It is proposed that IgM and IgG alloantibodies induce different conformational changes of the macrophage surface.

Footnotes

¹ This work was supported by the grant of National Institutes of Health, Bethesda, Maryland (Polish-American Agreement No. 05-04201) and Research Grants CA-08593 and A1-10497.