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B Lymphocyte Differentiation Induced by Lipopolysaccharide

II. Response of Fetal Lymphocytes¹

From the Spain Research Laboratories, Departments of Pediatrics and Microbiology and Institute of Dental Research, University of Alabama in Birmingham, Birmingham, Alabama 35294

Abstract

Cultures of mouse fetal liver and spleen, stimulated by bacterial lipopolysaccharide, gave rise to plasma cells staining for IgM, IgG2, IgG1, and IgA. Cells containing IgM and IgG2 were found in cultures from 17-day fetuses, coincident with the appearance of B lymphocytes bearing cell-surface IgM. IgG1- and IgA-containing cells were induced in cultures from 19-day fetuses and 1-day-old mice. The capacity to give rise to immunoglobulin-secreting cells of all classes preceded the development of a significant proliferative response to LPS; the proportions of cells staining for each class reached adult values by 1 day of age whereas the proliferative response did not mature until 3 weeks.

Footnotes

¹ This work was supported by United States Public Health Service Grants A111502, CA16673 and DE02670. A preliminary account was presented at the Federation of American Societies for Experimental Biology, Atlantic City, New Jersey, April 14–18, 1975.

² Recipient of NIH Research Career Development Award AI70780.