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Enduring Antibody Responses in "Normal" Rabbits to Maternal Immunoglobulin Allotypes¹

From the Department of Immunology, The Public Health Research Institute of The City of New York, Inc., New York, New York 10016

Abstract

A majority of rabbits born to mothers heterozygous with respect to the b locus allotypic markers "spontaneously" develop antibodies against the noninherited maternal allotypes. Such antibodies generally appear in the 4- to 5-month-old rabbit, after what may be a transient period of tolerance, and persist at constant levels for at least 5 to 6 months. The finding of a high incidence of measurable antimaternal allotype responses in "normal" rabbits, added to similar findings by others in mice, pigs, and man, underscores the generality of this rather unexpected phenomenon and invites further inquiries into biological significance.

Footnotes

¹ This work was supported in part by Grant GB 29018X from the National Science Foundation, and Grant AI-11940 from the National Institute of Allergy and Infectious Diseases.

² Address correspondence to Frank L. Adler, Div. Immunology, St. Jude Children's Research Hospital, P. O. Box 318, Memphis, Tennessee 38101.