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The Journal of Immunology, 1975, 115: 332-334.
Copyright © 1975 by The American Association of Immunologists, Inc.
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Thymus Influence on the Conversion of 19S to 7S Antibody Formation in the Response to TNP-Brucella1

Thomas J. Romano2 and G. Jeanette Thorbecke

From the Department of Pathology, New York University School of Medicine, New York, New York

Abstract

Serially transferred LAF1 spleen cells show a deficient 7S PFC response to TNP-Brucella when Tx as compared to normal irradiated intermediate hosts are used. This defect can be corrected by combining the spleen cells with lymph node cells from the Tx intermediate hosts. It is concluded that T helper cells, residing primarily in lymph node, are needed for efficient 19S->7S conversion in the immune response.

Footnotes

1 This work was supported by Grant AI-3076 from the United States Public Health Service.

2 Recipient of National Institutes of Health Training Grant No. 5GM01668-11 from the National Institute of General Medical Science.






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