HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Kook, A. I. Articles by Trainin, N. Search for Related Content PubMed Articles by Kook, A. I. Articles by Trainin, N.

The Control Exerted by Thymic Hormone (THF) on Cellular cAMP Levels and Immune Reactivity of Spleen Cells in the MLC Assay¹

From the Department of Cell Biology, The Weizmann Institute of Science, Rehovot, Israel

Abstract

We have shown previously that THF induces immunocompetence in lymphoid cells through the control of cellular cAMP levels and DNA synthesis. By the use of a one-way MLC assay it was now shown that the exposure of spleen cells to THF is accompanied by an increase, in the proliferative response of the responding cells. These effects are mediated by regulation of cellular levels of cAMP during the course of the MLC response. Thus, substances which modify cellular levels of cAMP such as DBcAMP, theophylline, and imidazole change the reactivity of cells exposed to THF in the MLC assay. It was also found here that cellular cAMP levels are critical in controlling the reactivity of normal spleen cells in the absence of THF. It is suggested that THF increases the number of competent cells in the spleen cell population capable of responding to antigenic stimulation in the MLC assay.

Footnotes

¹ This work was supported by a grant of the Talisman Foundation, New York and by the National Institutes of Health, Agreement NCI-G-72-3890.

² Send all correspondence to Dr. A. I. Kook, Department of Cell Biology, The Weizmann Institute of Science, Rehovot, Israel.

³ Harold L. Korda Professor of Cancer Research. Established Investigator of the Chief Scientist's Bureau Ministry of Health, Israel.