HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Warren, J. R. Articles by Metzger, J. F. Search for Related Content PubMed Articles by Warren, J. R. Articles by Metzger, J. F.

Evidence for Cell-Receptor Activity in Lymphocyte Stimulation by Staphylococcal Enterotoxin

From the U. S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland 21701 and the Department of Pathology and Oncology, University of Kansas Medical Center, Kansas City, Kansas 66103

Abstract

A wide dose-response curve and the inhibitory effect on mitogenicity of specific antitoxin suggest that polyclonal lymphocyte activation by staphylococcal enterotoxin requires direct interaction of toxin with lymphocyte receptors of low avidity for the protein. Staphylococcal enterotoxins A, B, and C₁ demonstrated equivalent mitogenic activity. Lymphocyte receptors involved in enterotoxin activation thus appear to be specific for nonantigenic regions of the toxin molecule. Monosaccharide (hapten) inhibition data indicate that lymphocyte receptors for staphylococcal enterotoxin lack -mannoside, galactose, acetylgalactosamine, acetylglucosamine, and fucose (or closely related saccharides) as determinant sugars and thus differ significantly in structure from lectin cell receptors.

Footnotes

¹ Send correspondence to: John R. Warren, Department of Pathology and Oncology, University of Kansas Medical Center, Kansas City, Kansas 66103.