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The Immune Response to a Synthetic Amino Acid Terpolymer in Man: Relationship to HL-A Type¹

From the Division of Clinical Immunology, Department of Medicine, National Naval Medical Center; Division of Experimental Medicine, Naval Medical Research Institute; and the Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014

Abstract

The immune response to the synthetic amino acid terpolymer (L-glutamic acid⁵⁵ L-lysine³³ L-tyrosine¹⁵)n (GLT) was studied in normal human volunteers. Delayed skin test reactivity to this antigen was seen in 34 of 61 subjects immunized with 150 µg of GLT. No antibody to GLT was detected in these responding individuals. There was a close correlation between the in vivo skin reactivity of volunteers to GLT and the ability of their lymphocytes to produce migration inhibitory factor (MIF) in response to GLT in vitro. However, a similar correlation was not seen when the in vitro proliferative response of lymphocytes to GLT, as measured by [methyl-³H] thymidine ([³H]TdR) incorporation, was assayed.

HL-A typing of volunteers was studied to determine if responsiveness to GLT was correlated to HL-A type. No statistical association was seen after correction was made for the number of individual HL-A antigens.

Footnotes

¹ This work was supported by CIP study unit CI 3-06-132 and the Bureau of Medicine and Surgery Work Unit No. MS51.524.013.1012AB2I. The opinions or assertions contained herein are the private ones of the authors and are not to be construed as official or reflecting the views of the Navy Department or the naval service at large.