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The Journal of Immunology, 1975, 114: 1638-1640.
Copyright © 1975 by The American Association of Immunologists, Inc.
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Distinction between Malignant L Cells and Normal Mouse Fibroblasts by Rosette Formation with Sheep Red Blood Cells1

James A. Hoch2, Manfred P. Dierich3, Michele A. Pellegrino, Soldano Ferrone4 and Ralph A. Reisfeld

From the Departments of Microbiology and Molecular Immunology, Scripps Clinic and Research Foundation, La Jolla, California 92037

Abstract

Murine L cell fibroblasts, and derivatives were found to rosette with sheep red blood cells (SRBC). Primary fibroblast explants from the parent murine strain, C3H, did not possess this potential. No rosettes were observed with primary fibroblast explants from C57BL and B10Br mice, with a human fetal lung fibroblast, with baby hamster fibroblasts or their polyoma transormed derivative, or with a cell line, 1T-22, derived from BALB/c mice. Hybridization of 1T-22 and L cells, by Sendai virus-mediated cell fusion, suppressed the rosette potential of the L cell parent. The receptor for SRBC on L cells appears to result from the expression of a recessive characteristic.

Footnotes

1 This is Publication No. 935 from the Department of Molecular Immunology, Scripps Clinic and Research Foundation. This work was supported by United States Public Health Service Grants GM 19416, AI 07007, and AI 10180.

2 J. A. H. is a Faculty Research Associate Awardee (PRA-66) of the American Cancer Society.

3 M. P. D. is a visiting scientist from the Institute Für Medizinische Mikrobiologie, Johannes Gutenberg Universität, Mainz, Germany. He is supported by Deutsche Forschungsgemeinschaft, Bad Godesberg, Germany.

4 S. F. is a visiting scientist from the University of Milan, Italy.






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