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Stimulator T Cells: Involvement in the Induction of Cell-Mediated Cytotoxicity¹

From The Salk Institute for Biological Studies, The Armand Hammer Center for Cancer Biology, San Diego, California 92112

Abstract

Spleen cells of mice primed by injection of normal or formaldehyde-treated allogeneic or xenogeneic tumor cells show a dramatically enhanced capacity to generate cytotoxic cells in vitro. This effect appears to be due to priming of a relatively anti-Thy-1 resistant T cell, which does not display immunologic specificity.

Footnotes

¹ Financial support was provided via Grant CA 15581 from The National Cancer Institute.