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The Induction of Delayed Hypersensitivity in Guinea Pigs to Poly U and Poly A:U¹

From the Northwestern University Medical School, Department of Microbiology, 303 E. Chicago Ave., Chicago, Ill. 60611

Abstract

Guinea pigs were sensitized to poly U and poly A:U so that subsequent stimulation of spleen cells from these immunized animals with poly U and poly A:U resulted in the production of migration inhibitory factor (MIF). MIF was also produced when spleen cells from animals immunized with poly A:U were cultured in the presence of mycobacterial RNA or whole viable H37 Ra cells. Negative dermal reactions were observed when guinea pigs immunized with poly A, poly U, or poly A:U were skin tested with these same synthetic nucleotides.

Footnotes

¹ This investigation was supported by Public Health Service Research Grant AI-01636 from the National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, Maryland.