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Splenic Regulation of the Clinical Appearance of Small Tumors¹

From the Department of Dermatology and Department of Pathology, Yale University Medical Center, New Haven, Connecticut 06510

Abstract

The Cloudman (S91) melanoma elicits an immune response in syngeneic DBA/2 mice which prolongs the time before the tumor becomes detectable but does not significantly alter the growth rate subsequent to its appearance. The spleen can either enhance the immune response and prolong the lag phase when stimulated with high doses of tumor cells or suppress it and shorten the duration at lower doses. This bidirectional effect of the spleen is similar to previously reported activity of regulatory T cells which reside in the spleen. This observation is discussed in contrast to the role of the spleen in animals bearing tumors which elicit concomitant immunity.

Footnotes

¹ This work was in part supported by American Cancer Society Grant and the United States Public Health Service Grant 04679, and the Dermatology Foundation, and the National Institutes of Health Grants CA 08593, AI 10,497, and Contract Grant CB 43994.

² Requests for reprints should be addressed to: Dr. James J. Nordlund, Department of Dermatology, Yale University Medical Center, 333 Cedar Street, New Haven, Connecticut 06510.