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Studies on the Cytophilic Properties of Human ₂ Microglobulin¹

From the Division of Allergy and Clinical Immunology, Department of Medicine, National Jewish Hospital and Research Center, Denver, Colorado 80206

Abstract

Human ₂microglobulin is cytophilic for mouse, rat, and to a lesser extent guinea pig lymphocytes and polymorphonuclear leukocytes but not for human, rabbit, chicken, frog, and turtle cells, nor for any mature erythrocytes tested. Mouse splenic lymphocytes bind 5- 7-fold more ₂microglobulin than thymocytes although hydrocortisoneresistant thymocytes resemble spleen cells in this regard. The ₂microglobulin binding by B and T cells in mouse spleen is similar. The structure responsible for ₂ microglobulin binding to the surface of cells is distinct from the Fc receptor specific for aggregated IgG.

Footnotes

¹ This work was supported by United States Public Health Service Grants AI 09758, CA 15895, AI 12136, and American Heart Association Grant 74856.