HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Morrison, D. C. Articles by Henson, P. M. Search for Related Content PubMed Articles by Morrison, D. C. Articles by Henson, P. M.

The Initiation of Mast Cell Degranulation: Activation at the Cell Membrane¹

From the Department of Immunopathology, Scripps Clinic and Research Foundation, LaJolla, California

Abstract

The low molecular weight mast cell activator, polymyxin B, has been covalently bound to an insoluble matrix of Sepharose 4B. It has been demonstrated that mast cells in preparations of rat peritoneal cells bind to Sepharose 4B-polymyxin B beads but not to control beads. The bound cells are stimulated to degranulate by this interaction at the cell membrane with the resultant release of biogenic amines.

Footnotes

¹ This is Publication 761 from the Department of Immunopathology, Scripps Clinic and Research Foundation, La Jolla, California. This work was supported by the United States Public Health Service Grant AI-07007, the American Heart Association, the Council for Tobacco Research, and GMS Grant GM 19322-02.

² Supported by United States Public Health Service Training Grant 5-TO1-GM00683-13.

³ Recipient of United States Public Health Service Career Development Award GM42567-04.