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Migration Inhibitory Activity in Serum and Cell Supernatants in Patients with Sezary Syndrome¹

From the Department of Pathology, University of Connecticut Health Center, Farmington, Connecticut 06032 and the Laboratory of Immunology, National Institutes of Allergy and Infectious Diseases, and the Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014

Abstract

The abnormal lymphocytes from patients with the Sezary syndrome produce macrophage migration inhibitory factors (MIF) both in vitro and in vivo. Five of six individuals studied had significant serum MIF activity and one had borderline activity. In contrast, in this study 47 normal individuals and 9 of 10 patients with extensive skin disease other than that of the Sezary syndrome had no such activity. Since the neoplastic T cells in patients with the Sezary syndrome localize in the skin, their production of chemical mediators in that site may be responsible for the generalized exfoliative erythroderma seen in that disease.

Footnotes

¹ This investigation was supported by Grant 12477 from the National Institutes of Health.

² Reprint requests should be addressed to: Dr. Takeshi Yoshida, Department of Pathology, University of Connecticut Health Center, Farmington, Connecticut 06032.