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Listeria Cell Wall Fraction: A B Cell Mitogen¹

From the Division of Clinical Immunology, University of Colorado Medical School, Denver, Colorado 80220 the Division of Allergy and Clinical Immunology, National Jewish Hospital, Denver, Colorado 80206 and the Department of Microbiology, George Washington University Medical School, Washington, D.C. 20037

Abstract

A crude cell wall-rich fraction of Listeria monocytogenes contains a substance or substances which cause blast transformation and thymidine incorporation by mouse spleen cells. The substance, Listeria cell wall fraction (LCWF), is a B cell mitogen in the mouse. It is not endotoxin, in that it stimulates B cells in C3H/HeJ mice. It is weakly mitogenic for rat spleen cells and not at all mitogenic for human peripheral blood or tonsil lymphocytes. Thus, it is dissimilar to both endotoxin and purified protein derivative (PPD) in its spectrum of activity. A cell wall-associated mitogen may play an early role in Listeria resistance.

Footnotes

¹ This work was supported by Grants AI-11661, AI-11240, and AI-10398 from the National Institutes of Health, and Grant IC-94 from the American Cancer Society.

² Present address: Department of Pediatrics, Medical College of Virginia, Richmond, Virginia 23298.