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Antigen-Specific and Nonspecific Mediators of T Cell/B Cell Cooperation

I. Evidence for Their Production by Different T Cells¹

From the Department of Microbiology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642

Abstract

Evidence is presented for two types of helper T cells in the mouse specific for a protein antigen, keyhole limpet hemocyanin (KLH). The first cell is able to help B cells respond to the hapten, trinitrophenyl (TNP), when coupled to KLH presumably through the participation of KLH-specific T cell factors. The second helper cell when stimulated with KLH is able to help B cells respond to red blood cell antigens, but not TNP-KLH, through the production of a non-antigen-specific factor.

Both types of helper cells were shown to be present in the spleens of KLH-primed mice, although they occurred with different frequencies. They were shown to be different T cells by their segregation from each other in vitro at limiting dilution.

Footnotes

¹ This work was supported by United States Public Health Service Research Grants AI-11558 and CA 11198 and American Cancer Society Research Grant IM-49.

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