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The Cytotoxic Effector Potential of Some Common Non-Lymphoid Tumors and Cultured Cell Lines with Phytohemagglutinin and Heterologous Anti-Erythrocyte Antisera

From the Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014

Abstract

We have found that a) phytohemagglutinin can induce red blood cell cytolysis by non-lymphoid tumors and cell lines, b) rabbit anti-chicken red blood cell antibody but not turkey anti-chicken red blood cell antibody can mediate an antibody-directed cellular cytotoxicity type of cytotoxicity utilizing P815Y mastocytoma cells or rat embryo fibroblasts as effectors, and c) none of these cell line effectors was capable of killing metabolically active cultured cell line targets in the presence of phytohemagglutinin.