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Identification of Macrophage-Like Characteristics in a Cultured Murine Tumor Line

From the Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014

Abstract

A mouse tumor line P388D₁ passaged in tissue culture for many years has been characterized morphologically and functionally as a macrophage like cell. P388D₁ cells phagocytize latex particles and firmly adhere to glass and plastics. In addition they have been shown to carry cell-bound receptors for immunoglobulin (Fc) and complement (C3). They fail to stain with fluorescent anti-mouse Ig or heterologous anti-mouse. Functionally, these cells exhibited high effector activity in an antibody-dependent, cell-mediated cytotoxic system. The accessibility of well characterized and pure macrophage-like cell lines, such as P388D₁, will facilitate studies where cell purity is essential.

Footnotes

¹ Present Address: Department of Medicine, Division of Immunology, University of Minnesota School of Medicine, Minneapolis, Minnesota 55455.