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Induction of Tolerance to Nucleic Acid Determinants by Administration of a Complex of Nucleoside d-Glutamic Acid and d-Lysine (D-GL)¹

From the Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115

Abstract

The administration of nucleosides coupled covalently to the copolymer of D-glutamic acid and D-lysine (D-GL) or to its stereoisomer, L-GL, induces a state of nucleoside (NUC)-specific tolerance in inbred SJL and BALB/c mice, irrespective of their immune status at the time of treatment. Such tolerance is characterized by the inability of treated animals to mount either primary or secondary, intact or adoptive, anti-NUC antibody responses following immunization with a highly immunogenic conjugate of NUC-Keyhole limpet hemocyanin. These observations have potential therapeutic importance in autoimmune processes involving anti-DNA antibody production.

Footnotes

¹ This investigation was supported by Grant AI-10630 from the National Institutes of Health, United States Public Health Service.

² Recipient of a Research Training Fellowship awarded by the International Agency for Research on Cancer.