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Anti-Ig-Triggered Movements of Lymphocytes—Specificity and Lack of Evidence for Directional Migration¹

From the Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115

Abstract

Interaction of anti-immunoglobulin antibodies with the surface Ig of B lymphocytes leads to capping and endocytosis of the immune complexes and to a brief stimulation of translational motility. Lymphocytes are not stimulated to move by interaction with other ligands, such as antibodies to the theta isoantigen, to H2 determinants, or to determinants recognized by heterologous anti-lymphocyte antibodies. Furthermore, anti-lymphocyte antibodies block the motility produced by anti-Ig. This effect was not seen in cells treated with colchicine, suggesting that the antilymphocyte effect may be associated with hyperstabilization of microtubules. Finally, we report on preliminary experiments using chemotactic chambers which show that anti-Ig stimulates random but not directional movement.

Footnotes

¹ This study was supported by National Institutes of Health Grant AI-10091. George Schreiner was supported by a Karin Grunebaum Cancer Research Foundation Fellowship. Emil Unanue is a recipient of a Research Career Award from the National Institutes of Health.