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In Vitro Detection of Immune Responses to Mtv-Induced Mammary Tumors: Qualitative Differences in Response Detected by Time Studies¹

Department of Bacteriology and Immunology and the Cancer Research Laboratory, University of California, Berkeley, California 94720

Abstract

Both BALB/cfC3H females neonatally infected with mammary tumor virus (MTV) and MTV-free BALB/c females possess spleen cells capable of significant activity against target-MTV-induced mammary tumor cells in in vitro microcytotoxicity tests. The responses of the BALB/cfC3H and BALB/c females are different, however, on the basis of time studies. Further, the reactivity characteristic of virgin BALB/cfC3H females is increased in parous females, and part of this reactivity is subsequently lost in multiparous females bearing large tumors. BALB/cfC3H females possess reactive spleen cells as early as 3 weeks of age, indicating that response to MTV antigens develops soon after birth in these neonatally infected mice.

Footnotes

¹ This work was supported by Public Health Service Research Grant CA-05388 from the National Cancer Institute and by cancer research funds of the University of California.