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Antigenic Relationship between the Fourth Component of Human and Guinea Pig Complement¹

Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014

Abstract

Antigenic similarity between cell-bound human and guinea pig C4 was detected with antisera specific for each of these molecules. No cross-reaction could be detected between C4 of normal guinea pig or human sera or after treatment of the sera with antigen-antibody C1 complexes. The cross-reactivity between cell-bound human and guinea pig C4 may reflect conformational changes in the C4 molecule as a result of binding to the cell surface.

Footnotes

¹ A preliminary version of this paper was presented at the 58th Annual FASEB meeting, April 7 through 12, 1974 (Fed. Proc., 33: 795, 1974).