HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Galanaud, P. Articles by Borel, Y. Search for Related Content PubMed Articles by Galanaud, P. Articles by Borel, Y.

Carrier-Determined Tolerance in Vitro¹

Rheumatology/Immunology Service, New England Medical Center Hospital and the Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts

Abstract

A primary immune response to normal BDF1 spleen cells was obtained in vitro to the T-independent antigen TNP-T4 coliphage. This anti-TNP response was suppressed by exposing the spleen cells for 6 hr to TNP bound either to isologous or heterologous -globulin. The suppression was hapten specific. In contrast, TNP-albumin conjugates did not induce tolerance in vitro.

Footnotes

¹ These studies were supported by U. S. Public Health Service Grant AI 11980 and the Damon Runyon Foundation, Grant DRG-1262.

² Recipient of Fellowship from Ministere des Affaires Etrangers, France. Present address: Groupe de Recherche de Nephrologies et d'Immunopathologie (INSERM) Hopital Beclere 92 140, Clamart, France.

³ Fellow of the Massachusetts Arthritis Foundation.