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Cellular Immunity to Leishmania Donovani

I. The Effect of T Cell Depletion on Resistance to L. Donovani in Mice¹

From the Department of Microbiology and Public Health, Michigan State University, East Lansing, Michigan 48824

Abstract

C57BL/6J mice were subjected to various combinations of immunosuppressive treatments and infected i.v. with amastigotes of Leishmania donovani. In normal mice the parasite population reached its peak about 24 days post-infection, after which parasite numbers gradually declined but they were still detectable on day 60. The course of infection was not altered in mice which had been thymectomized, lethally irradiated, and reconstituted with syngeneic marrow cells. Moderate lethally irradiated, and reconstituted with syngeneic marrow cells. Moderate suppression of acquired resistance resulted when thymectomized-irradiated mice were reconstituted with marrow cells which were previously treated with anti-brain associated serum and/or when recipient mice were treated with azathioprine on the same day they were infected. Splenectomy alone or together with irradiation failed to suppress immunity, but a long-lasting high level of immunosuppression resulted when splenectomy was combined with all the above treatments. These results suggest that 1) small numbers of thymus-dependent cells which survive irradiation and thymectomy or which may be present in the bone marrow may be sufficient to mount an immune response to L. donovani in mice, and 2) that T cells play an important role in acquired resistance to L. donovani in mice.

Footnotes

¹ This work was supported by Grant DADA 17-69C-9135 from the U.S. Army Medical Research and Development Command under sponsorship of the Commission on Parasitic Diseases of the Armed Forces Epidemiology Board, and with support from the Michigan Agricultural Experiment Station. Journal article No. 6790 from the Michigan Agricultural Experiment Station.

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