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Adjuvanticity of Synthetic Polynucleotides for Induction of Experimental Allergic Encephalomyelitis in Guinea Pigs¹

From the Samuel J. Sackett Research Laboratories and the Infectious Diseases-Hypersensitivity Section, Department of Medicine and the Department of Microbiology, Northwestern University-McGaw Medical Center, Chicago, Illinois 60611

Abstract

Complexes of polyadenylic acid and polyuridylic acid and complexes of polyinosinic acid and polycytidylic acid in incomplete Freund's adjuvant provide the prerequisite adjuvanticity for induction of experimental allergic encephalomyelitis in guinea pigs sensitized to spinal cord homogenate. The experimental allergic encephalomyelitis-adjuvanticity of these polynucleotide complexes resides in the pyrimidine component of each complex, i.e., polyuridylic acid and polycytidylic acid. These findings are discussed in the light of contemporary views linking viruses and nucleic acids to autoimmune disease of animals and man.

Footnotes

¹ This study was supported by Research Grants NB-06262 from the National Institute Neurological Diseases and Stroke and the James C. Hemphill Grant for research on multiple sclerosis (811-A-1) from the National Multiple Sclerosis of Society, as well as Training Grant AM-05069 from the National Institute of Arthritis, Metabolic and Digestive Diseases.