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Peyer's Patch Lymphocytes: Demonstration of the Integrity of Afferent and Efferent T-Cell Functions in the Guinea Pig and Rat¹

From the Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, and the Laboratory of Microbiology and Immunology, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland

Abstract

Guinea pig Peyer's patch cells respond to allogeneic cells in vitro in either the one-way or two-way mixed leukocyte reaction. Guinea pig and rat Peyer's patch cells produce a graft vs host (GVH) reaction in appropriate recipients. Guinea pig Peyer's patch cells liberate a lymphokine lymphocyte-derived chemotactic factor (LDCF) when stimulated by the T-cell mitogen concanavalin A. The presence of both the mixed leukocyte reaction and the GVH support the integrity of the afferent limb of T-cell immunity, since both measure the ability of T cells to recognize and respond to cell surface alloantigens. Both the GVH and the LDCF release to concanavalin A demonstrate that the efferent limb of C-cell immunity is also functional.

These studies reinforce the concept that Peyer's patch lymphocytes have the same immunologic potential as those in other peripheral lymphoid compartments.

Footnotes

¹ This paper was presented in part at the meeting of the American Association of Immunologists, April 12, 1974 and has appeared in abstract form in Federation Proceedings, 33: 803, 1974.