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The Journal of Immunology, 1974, 113: 1872-1875.
Copyright © 1974 by The American Association of Immunologists, Inc.
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Dissociation of T Cell Helper Function and Delayed Hypersensitivity

John Silver and Baruj Benacerraf

From the Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115

Abstract

The effect of tolerization with varying doses of deaggregated protein carrier on two T cell functions—delayed hypersensitivity (DHS) to the carrier and helper functions for the secondary anti-hapten antibody response to a hapten carrier conjugate—was studied. It was found that high doses of tolerogen inhibit the development of both DHS and helper function, while low doses of tolerogen inhibit the development of helper function but not of DHS.






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