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Cellular Events in Tolerance

III. Carrier Tolerance As a Model for T Cell Unresponsiveness¹

From the Division of Immunology, Department of Microbiology and Immunology, Duke University Medical Center, Durham, North Carolina 27710

Abstract

Lewis rats pretreated with 10 mg of the soluble supernatant of ultracentrifuged sheep -globulins (ShIgSo) and challenged with trinitrophenylated (TNP)-ShIg in adjuvant initially developed significantly fewer anti-TNP plaque-forming cells than untreated controls. The effect was specific because ShIgSo tolerant rats responded normally to TNP-rabbit -globulin. Carrier tolerance lasted at least 6 months and could be induced with as little as 100 µg ShIgSo. Adoptive transfer experiments to irradiated recipients demonstrated that thymocytes could reverse carrier unresponsiveness. "Suppressor" cells were not detectable in carrier tolerant spleen populations. The diminution of responsiveness to TNP on a tolerated carrier thus provides a model for the study of T cell unresponsiveness in vivo.

Footnotes

¹ This work was supported by United States Public Health Service Grant AI 10716. Part of this work was presented at the 58th annual meeting of the American Association of Immunologists, April 1974.

² F.S. is a predoctoral fellow in the Medical Scientist Training Program, United States Public Health Service Training Grant GM-01678.

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