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The Journal of Immunology, 1974, 113: 1647-1649.
Copyright © 1974 by The American Association of Immunologists, Inc.
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Immune Hemolysis and a Basic Peptide from Cobra Venom1

Hidechika Okada and William Campbell

National Cancer Center Research Institute, Tsukiji, Tokyo and the Department of Bacteriology, Yokohama City University School of Medicine, Yokohama

Abstract

Sheep erythrocytes sensitized with antibody and the first seven components of complement (EAC1-7) undergo rapid hemolysis in the presence of the eighth component of complement (C8) and a basic polypeptide (direct lytic factor, DLF) isolated from cobra venom which synergistically reacts with phospholipase A in hemolysis. EAC1-7 cells are not lysed by either C8 or DLF alone. DLF reacts after the reaction of C8 on EAC1-7 and not before it. These results suggest possible phospholipase activity in activated C8 molecules.

Footnotes

1 This study was supported by Research Grants 801079 and 811105 from the Ministry of Education of the Japanese Government.






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