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Use of Genetically Defined Nude Mice in the Study of the Mixed Leukocyte Reaction

Institute of Medicial Science, University of Toronto and The Ontario Cancer Institute, Toronto, Canada

Abstract

The H-2 complex and M locus have been defined for two incipient inbred strains of mice carrying the nu mutation. The strains differ at both loci from each other and cells from nu/nu mice of these allogeneic strains have been used to examine the role of T cells in the one-way mixed leukocyte reaction (MLR). A positive MLR requires the presence of both an allogeneic difference, and T cells. Proliferation by T cells is not essential, however, the cultures must contain a cellular component allogeneic to the T cell containing population.

Footnotes

¹ Fellow of the Medical Research Council of Canada.

² Address all correspondence to Dr. B. Anne Croy, Division of Immunology, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada, M5G 1 x 8.

³ Associate of the Medical Research Council of Canada.