HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Benjamin, D. C. Articles by Hershey, C. W. Search for Related Content PubMed Articles by Benjamin, D. C. Articles by Hershey, C. W.

The Termination of Immunologic Unresponsiveness to the Cyanogen Bromide Fragments of Bovine Serum Albumin in Rabbits¹

Department of Microbiology, School of Medicine, University of Virginia, Charlottesville, Virginia 22901

Abstract

A specific unresponsive state to the cyanogen bromide fragments of bovine serum albumin (BSA) was terminated by injecting soluble native BSA. The quantity of antibody produced in response to primary injections of BSA was less than normal. Responses to booster injections were normal with a normal affinity for BSA. Antibody was produced to both sets of determinants on BSA (i.e., those to which the rabbits were unresponsive as well as those to which it was not). These results are discussed in relation to various proposed mechanisms of the maintenance and termination of the unresponsive state.

Footnotes

¹ This work was supported in part by United States Public Health Service Grant AI10225.

² Address reprint requests to D. C. Benjamin.