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The Termination of Immunologic Unresponsiveness to Bsa in Rabbits by Transfer of Normal Sibling Thymocytes¹

Department of Microbiology, School of Medicine, University of Virginia, Charlottesville, Virginia 22901

Abstract

The unresponsive state to bovine serum albumin (BSA) in rabbits was successfully terminated by adoptive transfer of normal sibling thymocytes. These rabbits eventually (13 weeks after transfer) produced normal levels of anti-BSA with normal affinity for BSA. In contrast, BSA unresponsive rabbits that received thymocytes from unresponsive siblings did not produce detectable antibody. The possibility of nonspecific stimulation of antibody formation or the co-transfer of B cells was eliminated. These results are discussed in relation to possible mechanisms for the maintenance of the unresponsive state.

Footnotes

¹ This work was supported in part by United States Public Health Service Grant AI10225.