HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Emeson, E. E. Articles by Thursh, D. R. Search for Related Content PubMed Articles by Emeson, E. E. Articles by Thursh, D. R.

Antigen-Induced Trapping of Immunospecific Lymphocytes in the Spleen¹

Department of Pathology, New York Medical College, Valhalla, New York 10595

Abstract

Tritium-labeled anti-chicken red blood cells (CRBC) and ¹⁴C-labeled anti-sheep red blood cells (SRBC) lymphocytes were adoptively transferred to three groups of syngeneic mice, previously challenged i.v. with CRBC, SRBC, or Brucella abortus (BA). Subgroups of each group were sacrificed at 24, 48, and 72 hr after challenge and the relative numbers of anti-CRBC to anti-SRBC lymphocytes present in the spleen, peripheral lymph nodes, and peripheral blood for each group of mice were inferred from the mean ³H/¹⁴C ratios of these tissues. The results of these studies clearly established that challenged spleens can selectively trap recirculating immunospecific lymphocytes. Selective trapping was maximum at 48 hr after challenge, but still persisted at a high level at 72 hr. An unexpected finding was the clear demonstration of a deficiency of immunospecific lymphocytes in the peripheral lymph nodes. This deficiency was maximum at 24 hr and then declined. The functional significance and implications of the selective trapping of immunospecific lymphocytes and the concomitant depletion of these cells in other tissues is discussed.

Footnotes

¹ This study was supported by Grants AI-09106, GRS-5501-RR 05398 from the United States Public Health Service, National Institutes of Health, and ACS-IN-96 from the American Cancer Society.