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Antibody-Dependent Cell-Mediated Cytotoxicity

III. Two Functionally Different Effector Cells¹

La Rabida University of Chicago Institute and the Department of Pathology, University of Chicago, Chicago, Illinois 60637

Abstract

Macrophages obtained from peritoneal exudate are effector cells for antibody-dependent cytotoxicity. This effector function is independent of phagocytosis, and it is not inhibited by EDTA or aminophylline. Cells functionally similar to those in peritoneal exudate can be obtained from the spleen, but a functionally different population is primarily responsible for cytotoxicity mediated by spleen cells. Effector function of these splenic cells is inhibited by EDTA and aminophylline. These splenic cells tend to adhere to plastic and their function is resistant to a high dose of x-irradiation.

Footnotes

¹ This work was supported by the following United States Public Health Service Grants: AI-11080, AI-09268, AI-10242, and AI-10457, and American Chemical Society Grant IC 21.

² Present address: Department of Clinical Chemistry and Laboratory Medicine, M.D. Anderson Hospital, Houston, Texas 77025.

³ Present address: Basel Institute for Immunology, 487 Grenzacherstrasse, CH-4058 Basel, Switzerland.

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