HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Scornik, J. C. Articles by Rowley, D. A. Search for Related Content PubMed Articles by Scornik, J. C. Articles by Rowley, D. A.

Antibody-Dependent Cell-Mediated Cytotoxicity

I. Differentiation from Antibody-Independent Cytotoxicity by "normal" IgG¹

La Rabida University of Chicago Institute and Department of Pathology and Biochemistry, University of Chicago, Chicago, Illinois 60637

Abstract

Antibody-dependent cytotoxicity is mediated by lymphoid cells carrying receptors for immunoglobulin. These receptors are specific for IgG since a) IgG, but not IgM or IgA antibodies, either in their polymeric or monomeric forms, are capable of inducing cytotoxicity and b) nonspecific IgG, but not nonspecific IgM or IgA, can inhibit antibody-dependent cytotoxicity. These receptors on effector cells can interact with heterologous antibodies, but affinity for homologous IgG is higher than for heterologous IgG. Normal IgG is not inhibitory in reactions which are known to be antibody-independent, e.g., lysis of allogeneic target cells by immunized spleen cells or cytotoxicity nonspecifically induced by phytohemagglutinin.

Footnotes

¹ This work was supported by United States Public Health Service Grants AI 10457, AI 9268, AI 11080, and AI 10242.

² Present address: Dept. of Clinical Chemistry and Laboratory Medicine, M. D. Anderson Hospital, Houston, Texas 77025.

³ Present address: Basel Institute for Immunology, Basel, Switzerland.

⁴ MSTP Trainee, Public Health Service Training Grant 2-TO5-GMO-1939-NIGMS.

⁵ Recipient of a United States Public Health Service Research Career Development award.

This article has been cited by other articles:

				J. Scornik Complement-dependent immunoglobulin G receptor function in lymphoid cells Science, May 7, 1976; 192(4239): 563 - 565. [Abstract] [PDF]