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Regulation of the Immune Response

X. Antigen-Antibody Complex Inactivation of Cells Involved in Adoptive Transfer¹

Departments of Bacteriology, Immunology, and Medicine, The University of Western Ontario, London, Ontario, Canada

Abstract

Spleen cells from nonimmune mice were exposed in vitro to immune complexes containing solubilized sheep erythrocyte antigen and anti-sheep erythrocyte antibody, and then washed thoroughly. These antigen-antibody treated spleen cells displayed a decreased ability to transfer an adoptive immune response against whole sheep erythrocytes into syngeneic lethally irradiated recipients. Treatment with solubilized antigen or antibody alone produced little or no immunosuppression. Antigen-antibody complex suppression of immune competence was demonstrated to be: 1) immunologically specific, 2) not a result of carryover and release of antigen-antibody complexes, 3) rapidly attained (1 hr), 4) dependent on the Fc portion of antibody at low concentrations of antigen-antibody complexes, 5) stable to incubation of the antigen-antibody treated and washed spleen cells in antigen-antibody complex-free environments (in vitro and in vivo), and 6) the result of inactivation of cell-type(s) other than or as well as macrophages. An in vivo counterpart of in vitro antigen-antibody inactivation is described.

Footnotes

¹ This work was supported by the Medical Research Council of Canada and the National Cancer Institute of Canada.

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