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Immunologic Evidence for Horizontal Transmission of MTV¹

Department of Bacteriology and Immunology and the Cancer-Research Laboratory, University of California, Berkeley, California 94720

Abstract

Adult BALB/c female mice raised in the laboratory colony possess spleen cells capable of significant cytotoxic activity against target mammary tumor virus-(MTV) induced mammary tumor cells. If BALB/c females are raised in isolation, their spleen cells are not reactive. Reactivity can be induced in isolated females by caging them with a mouse neonatally infected with MTV. These data provide immunologic evidence for the horizontal transmission of MTV.

Footnotes

¹ This work was supported by Public Health Service Research Grant CA-05388 from the National Cancer Institute, and by cancer research funds of the University of California.