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Induction of Tolerance to an Intracellular Protozoan (Toxoplasma Gondii) by Passively Administered Antibody¹

Division of Allergy, Immunology and Infectious Diseases, Palo Alto Medical Research Foundation and the Division of Infectious Diseases, Department of Medicine, Stanford University Medical Center, Palo Alto, California 94301

Abstract

The humoral antibody response to infection with the intracellular protozoan Toxoplasma gondii was suppressed in adult mice that had been injected with antiserum formed against the same parasite. A small proportion of the mice developed a state of tolerance to Toxoplasma, demonstrable by the absence of Toxoplasma antibody in their sera although Toxoplasma cysts were present in their brains. The tolerant state lasted for 60 days in six mice; between 60 and 90 days after infection, antibody was detected in five of them and in one, the tolerance lasted for 90 days. By day 120 of infection all animals had antibody levels similar to controls.

Footnotes

¹ This study was supported by Public Health Service Grant AI 04717 from the National Institute of Allergy and Infectious Diseases and by a grant from Conselho Nacional de Pesquisas, Brazil.