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Requirement of Thymus-Derived -Positive Lymphocytes for Rejection of DNA Virus (SV40) Tumors in Mice¹

Department of Pathology and Cancer Research Center, Tufts University School of Medicine, Boston, Massachusetts 02111 and Division of Biochemistry, Department of Human Biological Chemistry and Genetics, The University of Texas Medical Branch, Galveston, Texas 77550

Abstract

The nature of lymphocytes capable of inhibiting the growth of syngeneic papovavirus SV40 tumor cells in BALB/c was investigated by the tumor cell neutralization assay. Treatment of immune lymphocytes with anti-C3H () AKR sera in the presence of complement eliminated the lymphocytes capable of inhibiting tumor cells in vivo. Treatment of immune lymphocytes with normal AKR sera and complement had no effect. Lymphocytes filtered through nylon wool column, a procedure known to remove B lymphocytes, retained their capacity to inhibit tumor cells in vivo. Thymectomized, irradiated, and reconstituted mice failed to develop lymphocytes sensitized to SV40 tumor-specific transplantation antigen (TSTA). These results suggest that cellular immune response to SV40 tumor cells in syngeneic mice is mediated by -positive thymus-derived lymphocytes.

Footnotes

¹ This work was supported by research Grants CA-14939, CA-12924, CA-15419, and CA-14108 from the National Cancer Institute, National Institutes of Health, Bethesda, Maryland and a grant from John A. Hartford Foundation.

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