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Surface and Intracellular Markers of Mouse Mesenteric and Peripheral Lymph Node and Peyer's Patch Cells¹

From the Department of Pathology, New York University School of Medicine, New York, New York 10016

Abstract

The incidence of surface and internal T and B cell markers in mouse mesenteric and peripheral node and Peyer's patch lymphocytes is unique to each population. BALB/c Peyer's patches show a high frequency of cells with complement receptors, surface and internal -chain determinants, and surface and internal -chain determinants, and a low frequency of Thy-1-positive cells. Peripheral and mesenteric lymph nodes show an intermediate frequency of cells with complement receptors, external and internal -chains, and Thy-1 antigen. Mesenteric node cells can be distinguished from peripheral node cells by a higher frequency of cells with µ-chain on their surface, and by the presence, in a frequency comparable to that of Peyer's patch cells, of cells with surface and internal -chains. Discrepancies, particularly marked for the internal determinants of Peyer's patch lymphocytes, between the sum of frequencies for µ, , and heavy chains vs the incidence of -determinants, suggest either unbalanced synthesis of heavy and light chains, or a large proportion of cells containing an unidentified immunoglobulin class.

Footnotes

¹ Supported by National Institutes of Health Grants AI-09738, AI-09647, and CA-08627, and by a grant from the Council for Tobacco Research-U.S.A., Inc.

² Postdoctoral Fellow supported by Pathology Training Program, National Institutes of Health Grant GM000127.

³ Career Scientist of the Health Research Council of the City of New York under Contract I-474.

⁴ Recipient of Research Career Development Award I K04 AI-70653 from the National Institute of Allergy and Infectious Diseases.

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