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Immunogenicity of Lowly and Highly Derivatized Dinitrophenyl-Bovine -Globulin in Different Strains of Guinea Pigs¹

From the Department of Pathology, New York University School of Medicine, New York, New York 10016, and the Department of Medicine, Division of Allergy and Immunology, Cornell University Medical College, New York, New York 10021

Abstract

Guinea pigs immunized with lowly derivatized dinitrophenylated bovine gamma globulin produced large amounts of antibody directed against the carrier molecule and large amounts of antibody directed against the hapten. Guinea pigs immunized with a highly derivatized preparation did not produce antibody against the carrier but produced large amounts of antibody directed against the hapten. Both preparations provoked the production of about the same amount of anti-hapten antibody, but the lowly derivatized antigen provoked the production of anti-hapten antibody of higher average affinity.

Footnotes

¹ This work was supported by National Institutes of Health Grants AI-03075-15 and AM-13701.

² Career Scientist of the Health Research Council of the City of New York (I-593).