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The Journal of Immunology, 1974, 113: 1262-1270.
Copyright © 1974 by The American Association of Immunologists, Inc.
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Type-Specific Antibodies in Human Chlamydia Trachomatis Infections of the Eye1

Odeon C. Briones, Lavelle Hanna2, Ernest Jawetz, Chandler R. Dawson and H. Bruce Ostler

From the Department of Microbiology and the Proctor Foundation, University of California, San Francisco, California 94143

Abstract

Sera from humans with ocular chlamydial infections were examined for type-specific antibodies by immunofluorescence before and after extensive cross-absorption with type-specific antigens of Chlamydia trachomatis. In trachoma-inclusion conjunctivitis infections ascribable to types C, A, or F, and occasionally types B and E, the antibody response was so narrow and specific as to make serologic diagnosis of the infecting agent feasible. In other ocular or oculongenital infections with types B, Ba, E, and D, and with lymphogranuloma venereum, there was only a broad antibody pattern. In experimental infections with types F or D, the initial antibody response of volunteers was narrowly directed at the dominant type-specific antigen of the infecting strain; then it broadened with time to include cross-reactive antibodies. In sequential infections with different types, the antibody to the first infecting type was recalled to a higher level by the second, heterotypic infection. In some individuals, treatment with tetracycline drugs resulted both in regression of clinical activity and decrease in antibody titer. Perhaps such a serologic response may indicate loss of antigen and cure.

Footnotes

1 This work was supported in party by National Institutes of Health Grants EY-00186 and PL-480-07-075.

2 Address requests for reprints to Miss Lavelle Hanna, Department of Microbiology, University of California, San Francisco, California 94143.






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